Many years ago, Dr Butler arrived at the secret Weapon X facility and discovered that one of the subjects, Wade Wilson, was apparently cured of cancer but he had been driven insane by the procedure. Learning that they allowed Wilson to escape, Butler shot the head scientist and took command, ordering surveillance on Wilson, and a tank to be prepared for his cancer-stricken beloved….
Today, Wade Wilson A/K/A Deadpool breaks into a classy hotel to meet with Wolverine. D’Pool thinks someone is out to get him (and other Weapon X grads) based on the events of the previous issues and needs Logan‘s advice. Logan brushes him off. Wade then seeks out Captain America, who is engaged in combat with agents of A.I.M. Deadpool joins in and asks Cap if he knows of anyone targeting super-soldiers; Cap doesn’t but advises his new ally to find someone who can help him work through his troubles. Instead Deadpool heads to a bar where he implants a tracking device in his leg, then goes to spend the night at a recent murder scene, knowing it is now unoccupied. In the middle of the night, Wolverine awakens him to warn him that enemies are coming for him. The two Weapon X grads take on the interlopers with Pool heading to the roof to shoot down Butler’s helicopter….
The epilogue reveals the truth: Deadpool was captured without incident while he slept in the room; he is now in a stasis tank under the supervision of Dr Butler and dreaming of action….