Exhausted after the Hulk's fight with Boomerang, Bruce Banner is discovered by the Stranger, an alien superbeing (last seen in X-Men #18), who is planning to cleanse the Earth of its evil by exterminating humanity. He has chosen the Hulk to be his agent of destruction.
The Stranger uses one of his machines to increase his own power, enabling him to force the Hulk to obey him. His will enslaved by the alien master, Hulk sets out on an insane rampage.
Also in this issue: Betty Ross, Thunderbolt Ross, Glenn Talbot.